![]() ![]() The sensitivity and false-negative rate of FSE were 86.4% and 13.6%, respectively. Among metastatic SLNs, micrometastasis was found in 234 (16.8%). Seventy-one patients (1.7%) had confirmed pathologic N2 or N3 stage. Results: A total of 1,397 SLNs from 908 patients were confirmed to be metastatic. We evaluated factors associated with the false-negative results of FSE for SLNs using the Generalized Estimating Equations model. Methods: We reviewed the records of 4,219 patients who underwent SLNB for primary invasive breast cancer between 20 at the Severance Hospital. This study aimed to verify the accuracy of FSE for SLNs. Based on the results of frozen section examination (FSE), surgeons can decide to continue further axillary dissections. Therefore, intraoperative FSE for SLN should not be routinely performed for all breast cancer patients.Ībstract = "Purpose: Sentinel lymph node (SLN) biopsy (SLNB) is widely performed for axillary staging in patients with breast cancer. However, the false-negative results of FSE for SLNs based on the size of the metastatic node did not change our practice. ![]() Some patients may show transition in their permanent pathology due to the size of the metastatic node. Conclusion: Most patients were not indicated for axillary lymph node dissection. Several clinicopathological factors, including the size of SLN metastases, suspicious preoperative axillary lymph nodes, and luminal B subtype, were associated with a higher rate of false-negative results. Purpose: Sentinel lymph node (SLN) biopsy (SLNB) is widely performed for axillary staging in patients with breast cancer.
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